Tetrodotoxin (TTX) as a Therapeutic Agent for Pain

Tetrodotoxin (TTX) as a Therapeutic Agent for Pain

Blog Article

Tetrodotoxin (TTX) is a potent neurotoxin that blocks voltage-gated sodium channels (VGSCs).VGSCs play a critical role in neuronal function under both physiological and pathological conditions.TTX has been extensively used to functionally characterize VGSCs, which can be classified as TTX-sensitive or TTX-resistant channels according to their sensitivity to this toxin.

Alterations in the expression and/or function of some specific TTX-sensitive VGSCs Artichoke have been implicated in a number of chronic pain conditions.The administration of TTX Miscellaneous at doses below those that interfere with the generation and conduction of action potentials in normal (non-injured) nerves has been used in humans and experimental animals under different pain conditions.These data indicate a role for TTX as a potential therapeutic agent for pain.

This review focuses on the preclinical and clinical evidence supporting a potential analgesic role for TTX.In addition, the contribution of specific TTX-sensitive VGSCs to pain is reviewed.